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Acne-like rash shows cancer drug is working

Last Updated: 2004-09-30 12:26:01 -0400 (Reuters Health)

By Patricia Reaney

LONDON (Reuters) - An acne-like rash may be good news for colon cancer patients because it shows that a targeted therapy for the disease is working, Belgian scientists said on Thursday.

They found that the severity of the rash corresponded to the patient's response to ImClone Systems Inc's drug Erbitux and to the length of their survival.

Professor Eric Van Cutsem, at Gasthuisberg University in Leuven, presented his group's findings at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics in Geneva.

The investigators tested the drug in combination with the cancer treatment irinotecan in 346 patients with advanced colon cancer that failed to respond to at least two previous chemotherapy regimes.

Erbitux, which is also known as cetuximab, works by blocking a protein called epidermal growth factor that is found on the surface of some cells and plays a role in regulating cell growth.

It is approved for use with colon cancer patients who have not responded to other treatments. The drug is also being studied as a treatment for head and neck cancer and as a first-line drug for colon cancer. The researchers do not know why the rash develops but said its severity is important because it is an indication of the efficacy of the drug.

Eighty-seven percent of patients in the study developed the skin condition but those who had the most serious rash had a median survival of 13 months, compared to 4.9 months for patients with a mild reaction.

The survival time for patients who did not have the side effect was 2.1 months.

"The more the severe the rash, the more efficient the treatment is," said Van Cutsem. "We don't have a clear explanation why but it is an important finding."

Van Cutsem and his colleagues are doing further studies to learn more about the link between the rash and drug response.

Erbitux was at the centre of an insider trading scandal that landed ImClone's founder in jail and led to the conviction of U.S. lifestyle trendsetter Martha Stewart on charges of lying about a stock sale.

Copyright © 2004 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 

Allergen-Free Homes Won't Stop Kids' Asthma

 

September 30, 2004 09:01:47 AM PDT , HealthDay

 

By Steven Reinberg
HealthDay Reporter

 

THURSDAY, Sept. 30 (HealthDayNews) -- Reducing the levels of cat dander and dust mites in your home won't prevent your child from getting asthma, British researchers report.

This finding counters the common belief that asthma is caused by early exposure to allergens. Instead, asthma is caused by a combination of genetic and environmental factors, according to the report in the October issue of the British journal Thorax.

In fact, this finding adds to the growing body of evidence that early exposure to allergens might actually protect children from developing asthma.

"Among a group of very ordinary children born in a small town in the U.K. and followed from birth to the age of 5 to 6, levels of dust mite and cat allergens in the home were not related to their development of allergies or asthma," said lead author Dr. Paul Cullinan, a reader in respiratory epidemiology at the Imperial College School of Medicine's National Heart and Lung Institute in London.

"The most important factors were having a parent with asthma and being the first-born child in the family," he added.

In their study, Cullinan's team collected data on 625 children. The children were followed from birth. When they were 5.5 years-old, 552 were tested for allergic reactions to house dust mites, cat dander and grass pollen.

The researchers also asked the mothers whether their children had any episodes of wheezing in the past year. In addition, when the children were 8 weeks old, Cullinan's group measured the levels of allergens and dust samples taken from each home.

Testing showed that one of every 10 children was allergic to dust mites or cat dander, and that one in 14 had wheezing in the past year.

However, the researchers did not find any link between the levels of household allergens and allergies or wheezing. They did find that allergic reactions and wheezing could occur when allergen levels were low.

They also found that children whose fathers were susceptible to allergies were significantly more likely to show signs of asthma. In addition, asthma was more likely to be present in first-born children.

Based on their findings, the researchers don't see the need to reduce allergen levels to prevent asthma.

"Clinically, there seems little point in reducing allergen levels in the home as a way of preventing asthma and allergies; indeed it may even increase the risk," Cullinan said. "The issue of being the first child is intriguing. We suspect it is something to do with the way a woman's immune system deals with a first pregnancy."

"Don't be worried about dust and cats in the home as a means of preventing your child getting asthma," Cullinan advised -- cautioning, however, that "it may be a different matter if your child already has asthma." For these children, exposure to household dust mites and cat dander may trigger attacks.

There does appear to be, at very low allergen levels, sensitization and the development of tolerance to allergens, said Dr. Bruce P. Lanphear, the director of the Cincinnati Children's Environmental Health Center and a professor of pediatrics and environmental health at Cincinnati Children's Hospital Medical Center.

"This is important because it might modify how we approach prevention efforts for children," Lanphear said. "It is possible that lowering allergen levels, and then having them go up again, might cause some kids to have more severe asthma."

The finding "raises questions about the complexity of reducing allergen exposure and preventing children from developing asthma or controlling asthma," Lanphear said. "Understanding and controlling environmental risk factors for asthma is not going to be simple."

More information

The National Heart, Lung, and Blood Institute has a page on coping with childhood asthma.

 

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