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Fears mount over Asian bird flu

Workers remove chickens from pens in preparation for slaughter at a farm in Suphanburi province, Jan 2004

Millions of birds have been culled to try to stem the spread of the virus

A Thai woman who recently died of bird flu probably caught the disease from her daughter, the government has said.

If true, she would be the first person in the latest outbreak to get bird flu from another human rather than birds.

A case of human-to-human infection would renew fears that bird flu may one day combine with human flu to create a more deadly version of the disease.

But officials said this was likely to be an isolated case, and the WHO said it posed no "significant" public risk.

Klaus Stohr, head of the WHO's global influenza programme, said the latest case was possibly another example of a "non-sustained, inefficient, dead-end-street, human-to-human transmission".

But he said the WHO was still concerned in case the case was the beginning of a more widespread transmission.

Family struck

Pranee Thongchan, 26, died of the H5N1 bird flu virus on 20 September, shortly after her daughter is believed to have died of the same illness, Thailand's Ministry of Public Health said.

H5N1 BIRD FLU VIRUS

Worker on Thai farm hit by bird flu

Principally an avian disease, first seen in humans in Hong Kong, 1997

Almost all human cases thought to be contracted from birds

Isolated cases of human-to-human transmission in Hong Kong and Vietnam, but none confirmed

The daughter, Sakuntala, was cremated before tests were conducted, so it will never be known for certain that she had the virus.

A statement from the Public Health Ministry said Pranee Thongchan: "either contracted the virus from the environment in the village where the chickens died, or from the sick daughter who she was taking care of very closely at the hospital for a long period of time".

Pranee's sister, Pranom - who also looked after Sakuntala in hospital - was confirmed as suffering from bird flu on Monday, and is now recovering in hospital.

The ministry statement stressed that the family's case was an isolated one.

"This probable human-to-human transmission of avian influenza was related to a single index case and was limited within a family," it said.

To reassure those who fear a human-to-human link could lead to a new virulent strain of the virus, the statement added: "There is no evidence to suggest that the virus has mutated or re-assorted."

This is not the first suspected case of human-to-human transmission of bird flu.

In previous epidemics - such as that in Hong Kong in 1997 and an outbreak in several parts of Asia last year - officials were unable to rule out the possibility that a very small number of victims had contracted the disease from other humans.

'Crisis of global importance'

At least nine other people have died from bird flu in Thailand so far this year - and a further 19 in Vietnam - but all are thought to have contracted the disease from poultry.

Tens of millions of chickens and other poultry have already been killed by the disease, or culled in an attempt to stop the disease spreading.

Two UN agencies warned on Monday that bird flu was set to remain a serious threat to animal and human life worldwide for some time to come.

Bird flu was a "crisis of global importance", the UN Food and Agriculture Organization (FAO) and the World Organization for Animal Health (OIE) said in a joint statement.

They stressed that the virus continued to circulate in East Asia and urged governments to take more action.

While stressing that culling was the best way to tackle the problem, they added that vaccination against bird flu could be used as a complementary measure.

The BBC's science correspondent, Richard Black, says the warning by the UN-affiliated bodies is unusually stark.

 

Arteries already stiff in obese 7-year-olds: study

Last Updated: 2004-09-27 16:38:39 -0400 (Reuters Health)

WASHINGTON (Reuters) - Obese children as young as seven already have the beginnings of artery disease, Italian and U.S. researchers reported on Monday.

They found signs that the carotid arteries of 100 obese children were already becoming thick and stiff, as well as indications that the children may have a higher risk of diabetes.

"You can see vascular changes already this early in really obese children," said Dr. Maurizio Trevisan of the University at Buffalo in New York, who led the study.

"We know that obesity in childhood increases the risk of atherosclerosis and death in adulthood," he added. "It is important for parents of obese children to help their children control their weight and get early treatment for these obesity-associated risk factors."

Trevisan, Dr. Archangelo Iannuzzi of Cava de' Tirreni Hospital in Salerno, Italy, and colleagues report their findings in the October issue of Diabetes Care.

For their study they screened 100 children aged 6 to 14 brought to a clinic in Naples because they were overweight. They compared those children to 47 of normal weight.

On average, the obese children had higher insulin resistance -- a measure of tendency to diabetes -- than children of normal weight.

They also had higher blood pressure and cholesterol levels. For instance, the obese children had an average blood pressure of 120/76 while the normal weight children had an average pressure of 98/65.

Importantly, ultrasound scans showed the obese children had thicker and stiffer carotid arteries, the researchers said. The carotid arteries carry blood to the head.

"In adults, arterial thickening has been shown to be a precursor of arterial narrowing and to predict clinical coronary artery disease," said Trevisan.

An estimated 15 percent of U.S. children are overweight or obese and children in many European countries are catching up.

The study shows that obesity acts quickly to damage the arteries of children and that parents and doctors need to act quickly to protect them, the researchers said.

SOURCE: Diabetes Care, October 2004.

Copyright © 2004 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 

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