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Herbal therapy can interfere with prescription drugs

Last Updated: 2004-09-27 14:40:38 -0400 (Reuters Health)

By Alison McCook

NEW YORK (Reuters Health) - A long-used herbal drug taken to lower cholesterol may interfere with nearly 60 percent of all prescription drugs, including the popular anti-cholesterol drugs called statins, new research reports.

In a preliminary study, investigators found that the guggulsterone, the active ingredient in the herbal remedy gugulipid, causes changes in human and rodent cells that induce the body to break down many drugs, including cancer drugs and AIDS medications.

These findings demonstrate how important it is to inform your doctor of any herbal medicines you are taking, study author Dr. Jeff L. Staudinger of the University of Kansas in Lawrence told Reuters Health.

"People need to be careful about herbal medicines," he said. "Because, in fact, they are drugs."

Resin from the guggul tree has been used for more than 3,000 years in India to treat a range of disorders. Previous research showed that guggulsterone lowers cholesterol by blocking a substance that keeps the body from getting rid of cholesterol.

To investigate whether it is safe to take guggulsterone with prescription medicines, Staudinger and his colleagues examined the effects of guggulsterone on liver cells in laboratory experiments. Their findings appear in the Journal of Pharmacology and Experimental Therapeutics.

Staudinger suggested that guggulsterone likely affects other drugs because it binds to a protein known as pregnane X receptor (PXR). This, in turn, induces the body to "turn on" a gene that encodes another protein that breaks down many different types of drugs, thereby reducing their levels in the body, he noted.

Staudinger added that some anticancer drugs, such as cyclophosphamide, need to be broken down by PXR to become active. Guggulsterone may interfere by augmenting that process, thereby raising levels of the drugs in the body.

Moreover, guggulsterone appears to also turn some other drugs, such as acetaminophen, into toxic compounds.

He noted that another herbal remedy, St. John's wort, also activates PXR, and can therefore interfere with other drugs. He recommends that all herbal extracts be screened to determine if they affect PXR.

However, Staudinger noted that guggulsterone has been used for years, and is likely safe if people are not taking any prescription medications. However, guggulsterone should be used cautiously by people who take prescription drugs, he said.

SOURCE: The Journal of Pharmacology and Experimental Therapeutics, August 2004.

Copyright © 2004 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content, including by framing or similar means, is expressly prohibited without the prior written consent of Reuters. Reuters shall not be liable for any errors or delays in the content, or for any actions taken in reliance thereon. Reuters and the Reuters sphere logo are registered trademarks and trademarks of the Reuters group of companies around the world.

 

Health Highlights: Sept. 26, 2004

 

September 26, 2004 09:03:57 AM PDT , HealthDay

 

Here are some of the latest health and medical news developments, compiled by editors of HealthDay:

U.S. Signs Canadian Firm to Develop Plague Vaccine

The U.S. National Institutes of Health, concerned over the possibility of a bioterrorism attack, has enlisted a Canadian firm to develop a vaccine against the plague.

The plague wiped out one-third of the population of Europe in the 14th century, and the NIH wants a vaccine in the event that terrorists may have the highly infectious germ, Agence France-Presse reports.

The NIH has awarded an $8 million grant to Vancouver-based ID Biomedical Corp. to find a vaccine that can be delivered using the company's Proteosome nasal spray to deliver the drug.

The NIH is concerned that bioterrorists will release the plague in the US. The problem with bio-terrorist agents: they're killers. Once you get them, virtually nothing can be done to save your life," company president Anthony Holler told AFP. "The economic impact of these things are so great to a society, that you should have a preventive treatment if there is a risk of that happening." Plague can be treated with antibiotics if symptoms show within 24 hours, but most people don't identify the early symptoms.

-----

City Sues to Compel HIV Treatment for Prostitute

The city of Amarillo, Tex., is trying to compel an HIV-infected prostitute to get treatment for the virus because she has spread it to at least one other person through her activities.

The lawsuit, which would pit civil liberties against public safety, is believed to be the first of its kind, at least in Texas, reports the Amarillo Globe-News.

"The Public Health Department assists many people with AIDS, and this single case is the very rare exception where a person who is HIV contagious is noncompliant with the health authority," City Attorney Marcus Norris told the Globe-News. "We believe that by her conduct, she poses a health threat to the community, and so we're going to have to try to get the court to intervene and help."

The woman, identified in court papers only as T.T., contracted the virus in 2000, and did not disclose her status to the patient she infected, the newspaper reported. She has refused to seek treatment.

-----

Violence Begets Disease in Iraq

An outbreak of hepatitis E, a virulent form of the liver-damaging virus that is particularly harmful to pregnant women, is striking poor areas of Iraq, and officials are blaming violence that has damaged water and sewage systems.

The New York Times reports that 150 cases have been counted so far in Sadr City, a slum in northwest Baghdad, and another 60 in the poverty- and violence-marred town of Mahmudiya, which is 35 miles south of the Iraqi capital. However, the equipment to test for the disease is crude, and officials fear that the count could be much higher. Officially, five deaths have been reported.

Officials told the Times that the water supplies in those areas have deteriorated since the U.S. invasion. Attempts to rebuild those systems have been beaten back because both areas have been hotspots of violence, and engineers fear to venture out because they fear for their safety.

Residents of the areas have made crude taps into the main water lines, but the virus can seep into the water supply because of the failed sewage systems, the paper reported.

-----

U.S. Health Funds for Children Go Unspent

During the Republican National Convention, President Bush promised a $1 billion initiative to enroll millions of children in two health programs. But the Washington Post reports that the administration's actions don't square with its words because it intends to return $1.1 billion in unspent funds back to the U.S. Treasury.

The loss of that federal money means that six states taking part in the State Children's Health Insurance Program (SCHIP) face budget shortfalls next year, or enough money to provide health coverage for 750,000 uninsured youngsters nationwide, according to the Post account.

The move prompted child advocacy groups to criticize the president.

If the Bush administration really cared about covering uninsured children, one of the things it could do immediately is make sure this $1 billion is used for SCHIP," Debra Ness, president of the National Partnership for Women and Families, told the newspaper. "The irony is this president talks constantly about not leaving any child behind and how he is going to cover so many kids. In truth, that ended up being false. He's just moving money around."

-----

Vitamin E Can Rebuild Hearing

Vitamin E can help restore hearing in people who suddenly go deaf for unexplained reasons, a small new study suggests.

The BBC reports that researchers in Israel gave the antioxidant to half of a small group of 66 patients who lost their hearing in the previous eight days. Those on vitamin E fared the best.

These patients showed an improvement in their hearing of 75 percent or better by the time they were discharged from the hospital, and had even better improvement at later follow-up, according to the BBC account.

In as many as 15 percent of cases of what is called idiopathic sensorineural hearing hearing loss, no obvious cause can be cited. Some scientists say they've found evidence of oxygen damage in the inner ear of animals exposed to noise, or to drugs known to harm hearing, according to the news service.

 

Continue with:

Herbal therapy can interfere with prescription drugs Last Updated: 2004-09-27 14:40:38 -0400 (Reuters Health) By Alison McCook NEW YORK (Reuters Health) - A long-used herbal drug taken to lower cholesterol may interfere with nearly 60 percent of all prescription drugs, including the popular anti-cholesterol drugs called statins, new research reports.

MONDAY, Sept. 27 (HealthDayNews) -- The self-esteem of children who become overweight or obese is likely to fall, claims a new study that confirms what many heavy children and their parents already know. To determine if being overweight precedes a low self-esteem among children, or low-self esteem leads to becoming overweight, Australian researchers followed 1,157 children, aged 5 to 10 years at the start of the study, and evaluated their weight and self-esteem in 1997 and again in 2000.

MONDAY, Sept. 27 (HealthDayNews) -- Fortifying food with folic acid can greatly reduce the incidence of spina bifida and other birth defects, says a Canadian study in the latest issue of BMC Pregnancy and Childbirth. The study found a 78 percent reduction in the number of babies born with nerual tube defects in the province of Newfoundland and Labrador after the Canadian government made it mandatory in 1998 that folic acid had to be added to pasta, flour and cornmeal.

MONDAY, Sept. 27 (HealthDayNews) -- The vast majority of West Nile infections this year have occurred in West Coast and Rocky Mountain states, with almost no human infections recorded in the densely populated Northeast, where the virus first took hold five years ago. Overall, there have been just 10 cases of human infection with West Nile virus recorded this season from Maine to Washington, D.C.

(HealthDayNews) -- Here are the latest clinical trials, courtesy of CenterWatch: Bone Metastases A research study to determine if Radiofrequency Ablation (RFA) reduces the pain of metastatic bone tumors in patients who have not received adequate pain relief from conventional therapies. Volunteers who have one or two metastatic bone tumor(s) causing pain and whose pain persists when on pain medication may be able to participate.

Here are some of the latest health and medical news developments, compiled by editors of HealthDay: Stem Cells Found to Help Heart, Eyes Stem cells, plagued with political controversy because they are harvested from human embryos, have found separate experimental uses in helping the heart and eyes, the Washington Post reported Monday.

(HealthDayNews) -- When Tabby scratches or bites you, don't just dismiss her bad temper. You could get cat scratch disease, a bacterial infection. The condition is caused by Bartonella henselae bacteria, according to the U.S. Centers for Disease Control and Prevention. Warning signs include swollen lymph nodes, especially those around the head, neck and upper limbs. A person with cat scratch disease also may experience fever, headache, fatigue and a poor appetite.

MONDAY, Sept. 27 (HealthDayNews) -- A new type of T-cell that reduces asthma and airway inflammation in mice has been identified by scientists at the Stanford University School of Medicine. This finding reinforces the theory that a lack of regulatory T-cells, known as Tregs, is a prime cause of asthma and allergies.

 

SUNDAY, Sept. 26 (HealthDayNews) -- Now that fall has arrived, fireplace safety has become a burning issue. House fires and carbon monoxide poisoning are serious and potentially deadly dangers that can flare up if your fireplace is poorly built or maintained. Michigan State University thinks it's a hot topic and offers some advice on staying safe while you enjoy the cozy comfort of your fireplace.

 

 

 


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